NCBI PubMed NLMPubMed
My NCBI
[Sign In] [Register]
All Databases PubMed Nucleotide Protein Genome Structure OMIM PMC Journals Books
 Search for
Limits 
Preview/Index 
History 
Clipboard 
Details 
About Entrez

Text Version

Entrez PubMed
Overview
Help | FAQ
Tutorial
New/Noteworthy
E-Utilities

PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
Special Queries
LinkOut
My NCBI (Cubby)

Related Resources
Order Documents
NLM Catalog
NLM Gateway
TOXNET
Consumer Health
Clinical Alerts
ClinicalTrials.gov
PubMed Central

 Note: 
  Performing your original search, Vaginal absorption estriol, in PubMed will retrieve 15 citations.

 Display  Show 
All: 1 
Review: 0 
1: Maturitas. 1986 Oct;8(3):239-43. Related Articles, Links

Plasma oestriol following vaginal administration: morning versus evening insertion and influence of food.

Heimer GM, Englund DE.

The aim of this trial was to study the vaginal absorption of oestriol and to investigate whether morning rather than evening oestriol administration would produce different plasma oestriol patterns. The influence of food intake on plasma oestriol levels was also investigated. Nine post-menopausal women were given 0.5 mg oestriol (ovula supplied by Leo AB, Sweden) intravaginally every evening for 16 days. Thereafter, 1 mg oestriol was given every evening for another 5 days, except on treatment days 18 and 19 when 1 mg oestriol was given in the morning instead. Venous blood samples were collected at frequent intervals on day 19 (morning administration) and a meal was allowed 4 h later. On the day 21 (evening administration), venous blood samples were taken at frequent intervals during the night and no meal was given until the next morning. Plasma concentrations of unconjugated oestriol were measured by means of a specific radioimmunoassay (RIA). A difference was seen in the plasma oestriol patterns when the results following morning and evening administration were compared. However, no significant difference as regards the total 24-h systemic availability of oestriol was observed. A minimal increase in plasma oestriol levels was seen after a meal in the case of both morning and evening intravaginal oestriol administration, possibly as a result of enterohepatic recirculation.

MeSH Terms:
  • Absorption
  • Comparative Study
  • Estriol/administration & dosage*
  • Estriol/blood
  • Estriol/metabolism
  • Female
  • Food*
  • Humans
  • Kinetics
  • Menopause/metabolism
  • Middle Aged
  • Research Support, Non-U.S. Gov't
  • Time Factors
  • Vagina/metabolism*

Substances:
  • Estriol

PMID: 3784920 [PubMed - indexed for MEDLINE]


 Display  Show