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Performing your original search, Vaginal absorption
estriol, in PubMed will retrieve 15
citations. |
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Estriol: absorption after
long-term vaginal treatment and gastrointestinal absorption as
influenced by a meal.
Heimer G, Englund
D.
This study was designed to evaluate the vaginal absorption
of estriol when given as a 21-day treatment. Vaginal absorption was
compared with the oral absorption of a known estriol preparation
(TriovexR, Leo AB, Sweden). One mg of estriol was administered
intravaginally once a day for 21 days to 6 menopausal women. Plasma
concentrations of unconjugated estriol were measured by a specific
RIA-method at frequent intervals during 24 hours on the first and 21st
day of treatment. One month later, 10 mg of estriol was given once
orally and plasma estriol concentrations were measured in the same way.
At vaginal administration, the absorption of estriol was very effective.
When measured on the 21st day, the absorption had declined significantly
but was still nearly in the same range as after oral administration of
10 mg of estriol. At oral administration, there was an initial plasma
estriol elevation for 3 hours only followed by a second one immediately
postprandially. It is concluded that estriol is readily absorbed from
the vagina, but the absorption does decline significantly during
prolonged treatment. A large single oral dose of estriol provides
initially a high plasma estriol concentration but also a second one
induced by eating a meal, possibly indicating an enterohepatic
recirculation of estriol.
MeSH Terms:
- Administration, Oral
- Estriol/administration & dosage
- Estriol/blood*
- Female
- Food*
- Humans
- Intestinal Absorption*
- Middle Aged
- Research Support, Non-U.S. Gov't
- Suppositories
- Vagina/metabolism*
Substances:
PMID: 6507057 [PubMed - indexed for MEDLINE]
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