[Sign In] [Register]
All Databases PubMed Nucleotide Protein Genome Structure OMIM PMC Journals Books
 Search for
About Entrez

Text Version

Entrez PubMed
Help | FAQ

PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
Special Queries
My NCBI (Cubby)

Related Resources
Order Documents
NLM Catalog
NLM Gateway
Consumer Health
Clinical Alerts
PubMed Central

  Performing your original search, Vaginal absorption estriol, in PubMed will retrieve 15 citations.

 Display  Show 
All: 1 
Review: 0 
1: Acta Obstet Gynecol Scand. 1984;63(6):563-7. Related Articles, Links

Estriol: absorption after long-term vaginal treatment and gastrointestinal absorption as influenced by a meal.

Heimer G, Englund D.

This study was designed to evaluate the vaginal absorption of estriol when given as a 21-day treatment. Vaginal absorption was compared with the oral absorption of a known estriol preparation (TriovexR, Leo AB, Sweden). One mg of estriol was administered intravaginally once a day for 21 days to 6 menopausal women. Plasma concentrations of unconjugated estriol were measured by a specific RIA-method at frequent intervals during 24 hours on the first and 21st day of treatment. One month later, 10 mg of estriol was given once orally and plasma estriol concentrations were measured in the same way. At vaginal administration, the absorption of estriol was very effective. When measured on the 21st day, the absorption had declined significantly but was still nearly in the same range as after oral administration of 10 mg of estriol. At oral administration, there was an initial plasma estriol elevation for 3 hours only followed by a second one immediately postprandially. It is concluded that estriol is readily absorbed from the vagina, but the absorption does decline significantly during prolonged treatment. A large single oral dose of estriol provides initially a high plasma estriol concentration but also a second one induced by eating a meal, possibly indicating an enterohepatic recirculation of estriol.

MeSH Terms:
  • Administration, Oral
  • Estriol/administration & dosage
  • Estriol/blood*
  • Female
  • Food*
  • Humans
  • Intestinal Absorption*
  • Middle Aged
  • Research Support, Non-U.S. Gov't
  • Suppositories
  • Vagina/metabolism*

  • Suppositories
  • Estriol

PMID: 6507057 [PubMed - indexed for MEDLINE]

 Display  Show