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[Effectiveness of estriol depot
vaginal suppositories in postmenopausal women with urogenital
climacteric manifestations]
[Article in
German]
Kochli OR, Schar G, Beck B, Benz
J.
Thurgauisches Kantonsspital, Frauenfeld.
In this
study, 43 postmenopausal patients with urogenital complaints such as
vaginal dryness, incontinence, or bleeding with intercourse were treated
with weekly applications of Orthogynest vaginal estriol suppositories in
a new depot form. A marked increase in the vaginal epithelium (A.
Schmitt score) and a significant decrease in symptoms due to vaginal
atrophy were noted. The depot form allows for decreased dosing
frequency, leading to improved compliance. Systemic symptoms, such as
hot flashes and emotional lability, were also noted to respond to the
Orthogynest suppositories.
MeSH Terms:
- Administration, Intravaginal
- Climacteric/drug effects*
- Delayed-Action Preparations
- English Abstract
- Estriol/administration & dosage*
- Female
- Humans
- Middle Aged
- Prospective Studies
- Urinary Incontinence/drug therapy*
Substances:
- Delayed-Action Preparations
- Estriol
PMID: 1392633 [PubMed - indexed for MEDLINE]
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