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  Performing your original search, Vaginal absorption estriol, in PubMed will retrieve 15 citations.

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1: Maturitas. 1981 Mar;3(1):47-53. Related Articles, Links

Oestrogens, gonadotropins and prolactin after intra-vaginal administration of oestriol in post-menopausal women.

Keller PJ, Riedmann R, Fischer M, Gerber C.

Serum total oestrone, 17 beta-oestradiol and oestriol concentrations and FSH, LH and prolactin values were measured radioimmunologically in post-menopausal women before and after intra-vaginal application of 0.5 mg oestriol. While oestrone and oestradiol were not altered, there was a 3100% increase in the mean oestriol values within 1 or 2 h; pre-treatment levels were again reached 8 h later. Both gonadotropins were moderately decreased, the serum prolactin values appeared to be slightly elevated. Repeated intra-vaginal application of oestriol resulted in a significant rise of the mean serum oestriol levels while the other oestrogens remained unchanged. The same was true for FSH and LH, a considerable negative feedback was therefore excluded. Again there seemed to be a slight rise of the prolactin secretion. It was concluded that intra-vaginal administration of oestriol is a most suitable local and systemic oestrogen replacement therapy, which is more effective than the oral regimen.

MeSH Terms:
  • Absorption
  • Aged
  • Estradiol/blood
  • Estriol/administration & dosage*
  • Estriol/blood
  • Estriol/metabolism
  • Estrogens/blood*
  • Estrone/blood
  • Female
  • Follicle Stimulating Hormone/blood
  • Gonadotropins, Pituitary/blood*
  • Humans
  • Luteinizing Hormone/blood
  • Menopause/drug effects*
  • Middle Aged
  • Prolactin/blood*
  • Vagina

Substances:
  • Estrogens
  • Gonadotropins, Pituitary
  • Estriol
  • Estradiol
  • Estrone
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone

PMID: 6789033 [PubMed - indexed for MEDLINE]


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