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Performing your original search, Vaginal absorption
estriol, in PubMed will retrieve 15
citations. |
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Oestrogens, gonadotropins and
prolactin after intra-vaginal administration of oestriol in
post-menopausal women.
Keller PJ, Riedmann R,
Fischer M, Gerber C.
Serum total oestrone, 17 beta-oestradiol
and oestriol concentrations and FSH, LH and prolactin values were
measured radioimmunologically in post-menopausal women before and after
intra-vaginal application of 0.5 mg oestriol. While oestrone and
oestradiol were not altered, there was a 3100% increase in the mean
oestriol values within 1 or 2 h; pre-treatment levels were again reached
8 h later. Both gonadotropins were moderately decreased, the serum
prolactin values appeared to be slightly elevated. Repeated
intra-vaginal application of oestriol resulted in a significant rise of
the mean serum oestriol levels while the other oestrogens remained
unchanged. The same was true for FSH and LH, a considerable negative
feedback was therefore excluded. Again there seemed to be a slight rise
of the prolactin secretion. It was concluded that intra-vaginal
administration of oestriol is a most suitable local and systemic
oestrogen replacement therapy, which is more effective than the oral
regimen.
MeSH Terms:
- Absorption
- Aged
- Estradiol/blood
- Estriol/administration & dosage*
- Estriol/blood
- Estriol/metabolism
- Estrogens/blood*
- Estrone/blood
- Female
- Follicle Stimulating Hormone/blood
- Gonadotropins, Pituitary/blood*
- Humans
- Luteinizing Hormone/blood
- Menopause/drug effects*
- Middle Aged
- Prolactin/blood*
- Vagina
Substances:
- Estrogens
- Gonadotropins, Pituitary
- Estriol
- Estradiol
- Estrone
- Prolactin
- Luteinizing Hormone
- Follicle Stimulating Hormone
PMID: 6789033 [PubMed -
indexed for MEDLINE]
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