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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 55:B183-B190 (2000)
2000 The Gerontological Society of America

Estriol (E3) Replacement Improves Endothelial Function and Bone Mineral Density in Very Elderly Women

Toshio Hayashia, Izumi Itoa,b, Hatsuyo Kanoa, Hidetoshi Endob and Akihisa Iguchia

a Department of Geriatrics, Nagoya University School of Medicine, Japan.
b Department of Internal Medicine, National Chubu Hospital, Oobu, Japan.

Toshio Hayashi, Department of Geriatrics, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan E-mail: hayashi{at}med.nagoya-u.ac.jp .

Decision Editor: Jay Roberts, PhD

We investigated the effects of estriol (E3) on endothelial function and bone mineral density (BMD) in very elderly women. Twenty-four very elderly women (80 3.5 years old) were administered CaCl2 with or without estriol treatment (2 mg/day) for 30 weeks (hormone replacement treatment [HRT] group vs control group). Endothelium-dependent flow-mediated dilatation (FMD), endothelium-independent dilatation by nitroglycerin of the brachial artery, and BMD were assessed. Levels of plasma lipids and apoproteins were not changed; however, both plasma E3 and E2 were substantially increased (E2, 4.6 to 31.3 8.1; E3, <5 to 45.3 7.9 pg/mL) by HRT. The FMD value was also increased by HRT, as were the plasma nitrite/nitrate and cGMP values. The response to nitroglycerin was not changed. The BMD was increased by HRT, but decreased in the control group. There were significant differences between the HRT group and control group after 30 weeks' treatment in the levels of osteocalcin, P1CP, and urinary deoxypiridinoridine. E3 significantly improved BMD by inhibiting bone resorption. Endothelial function was improved in line with the antiatherosclerotic effects. E3 might be effective for use in HRT in elderly patients.




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