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Effect of
dehydroepiandrosterone on vaginal and uterine histomorphology in the
rat.
Sourla A, Flamand M, Belanger A, Labrie
F.
Laboratory of Molecular Endocrinology, CHUQ Research
Center and Laval University, Quebec,
Canada.
Dehydroepiandrosterone (DHEA) applied on the dorsal skin
of ovariectomized animals, at the twice daily dose of 30 mg, resulted in
a complete reversal of the vaginal atrophy seen 1, 3 and 6 months after
ovariectomy, and induced proliferation and mucification of the vaginal
epithelium. A similar mucification of the vaginal epithelium related to
androgenic action was observed in intact rats treated with DHEA. While
treatment of intact rats with DHEA resulted in a significant increase in
uterine weight at 1 month, the value of the same parameter decreased by
approximately 30% after 3 and 6 months of DHEA administration. In
ovariectomized DHEA-treated animals, uterine weight was increased at all
time intervals. At histopathological examination, following DHEA
administration to intact animals, stimulation was seen in the myometrial
layers of the uterus whereas atrophy, involving especially the
endometrium, became apparent after 3 and 6 months of treatment. In
ovariectomized animals, the endometrium remained atrophic at all time
intervals during DHEA treatment and the uterine epithelium thus remained
atrophic under DHEA treatment. Examination of the effect of DHEA on the
vaginal epithelium indicates that local application of DHEA on the
vaginal mucosa is approximately 10-fold more efficient than application
at a distant site on the skin. Reversal of the ovariectomy-induced
increase in serum LH levels was also observed after DHEA treatment. The
present data suggest that DHEA possesses a tissue-specific action,
through its local transformation into active estrogens in the vaginal
epithelium while the uterine epithelium remains atrophic. In addition,
the site of administration of DHEA appears to be a significant factor,
at least for its stimulatory effect on the vaginal mucosa.
MeSH
Terms:
- Administration, Intravaginal
- Animals
- Atrophy/drug therapy
- Cell Division
- Dehydroepiandrosterone/administration & dosage
- Dehydroepiandrosterone/pharmacology*
- Dehydroepiandrosterone/therapeutic use
- Endometrium/pathology
- Epithelium/metabolism
- Epithelium/pathology
- Female
- Luteinizing Hormone/blood
- Mucins/metabolism
- Mucous Membrane/drug effects
- Organ Size/drug effects
- Ovariectomy
- Rats
- Rats, Sprague-Dawley
- Uterus/drug effects*
- Uterus/pathology*
- Vagina/drug effects*
- Vagina/pathology*
Substances:
- Mucins
- Dehydroepiandrosterone
- Luteinizing Hormone
PMID: 9719448 [PubMed - indexed
for MEDLINE]
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