03
Oct
Testosterone and Lung Health
Testosterone has a great impact on every part of the body. Here are seven ways that it interacts and supports lung function.
On Lungs and Breathing (Pulmonary Function)
- Boosts overall lung strength and capacity.
- Helps with breathing issues in conditions like COPD by improving muscle power and
stamina during exercise. - May aid in repairing lung tissue and making breathing easier.
On Reducing Swelling (Inflammation)
- Acts like a natural anti-inflammatory, lowering harmful swelling in the body.
- Reduces risks for diseases like heart problems, diabetes, and cancer by calming overactive immune signals
- Helps control fat-related inflammation and improves how the body handles sugar.
On Immune System
- Balances the immune response to prevent it from overreacting, which can help with autoimmune diseases like multiple sclerosis.
- In people with low testosterone, boosting it can stabilize and normalize immune activity.
- May make the body less prone to excessive immune attacks.
On Asthma
- Lowers the chance and severity of asthma attacks by reducing airway tightness and allergic reactions.
- Provides protection against inflammation in the lungs, leading to better breathing.
Works better when testosterone is higher and estrogen is lower.
On COPD (Chronic Obstructive Pulmonary Disease)
- Slows down how fast COPD gets worse, especially in men with low levels.
- Builds muscle and improves body strength, making it easier to exercise and handle daily activities.
Cuts down on hospital stays and helps with overall lung function.
On Pulmonary Fibrosis (Scarring in Lungs)
- Linked to a lower risk of developing idiopathic pulmonary fibrosis.
- Helps maintain better lung capacity over time and slows tissue scarring.
- Protects cell health in the lungs, potentially delaying disease progress.
On Widening Lung Blood Vessels (Pulmonary Vasodilation)
- Helps relax and widen blood vessels in the lungs, improving blood flow and reducing pressure.
- Eases the heart’s workload, especially useful for conditions like pulmonary hypertension.
- Works at normal hormone levels without depending on sex and may offer heart and lung protection overall.
References
- Casaburi R, Bhasin S, Cosentino L, et al. Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;170(8):870-878. doi:10.1164/rccm.200305-617OC.
- Jones TH, Kelly DM. Randomized controlled trials – mechanistic studies of testosterone and the cardiovascular system. Asian J Androl. 2018;20(2):120-130. doi:10.4103/aja.aja_6_18.
- Creutzberg EC, Wouters EF, Mostert R, Pluymers RJ, Schols AM. Endocrinological disturbances in chronic obstructive pulmonary disease. Eur Respir J Suppl. 2003;46:76s-80s. doi:10.1183/09031936.03.00004610.
- Mohamad NV, Soelaiman IN, Chin KY. The relationship between circulating testosterone and inflammatory cytokines in men. Aging Male. 2019;22(2):129-140. doi:10.1080/13685538.2018.1482487.
- Bianchi VE. The Anti-Inflammatory Effects of Testosterone. J Endocr Soc. 2018;3(1):91-107. doi:10.1210/js.2018-00186.
- Malkin CJ, Pugh PJ, Jones RD, Jones TH, Channer KS. Testosterone as a protective factor against atherosclerosis-immunomodulation and influence upon plaque development and stability. J Endocrinol. 2003;178(3):373-380. doi:10.1677/joe.0.1780373.
- Muehlenbein MP, et al. Testosterone-mediated immune functions and male life histories. Am J Hum Biol. 2005;17(5):527-558. doi:10.1002/ajhb.20419.
- Lakshmikanth T, Consiglio C, Sardh F, Forlin R, Wang J, Tan Z, et al. Immune system adaptation during gender-affirming testosterone treatment. Nature. 2024;633(8028):155-164. doi:10.1038/s41586-024-07789-z.
- Ainslie RJ, et al. RISING STARS: Androgens and immune cell function. J Endocrinol. 2024;261(3):e230398. doi:10.1530/JOE-23-0398.
- Foo YZ, Nakagawa S, Rhodes G, Simmons LW. The effects of sex hormones on immune function: a meta-analysis. Biol Rev Camb Philos Soc. 2017;92(1):551-571. doi:10.1111/brv.12243.
- Chan YM, Bourchier H, Rey RA, et al. Effects of the Timing of Sex-Steroid Exposure in Adolescence on Adult Health Outcomes. J Clin Endocrinol Metab. 2019;104(10):4578-4586. doi:10.1210/jc.2019-00569.
- Baillargeon J, Urban RJ, Zhang W, et al. Testosterone replacement therapy and hospitalization rates in men with COPD. Chron Respir Dis. 2019;16:1479972318793004. doi:10.1177/1479972318793004.
- Svartberg J, Aasebø U, Hjalmarsen A, Sundsfjord J, Jorde R. Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial. Respir Med. 2004;98(9):906-913. doi:10.1016/j.rmed.2004.02.015.
- Ji Z, et al. EXPRESS: Exploring Testosterone’s Impact on Pulmonary Health in a Rat Model of COPD: Investigating MMP-9 and FGF-23. J Investig Med. 2025;10815589251378184. doi:10.1177/10815589251378184.
- Seftel A. Testosterone Treatment Improves Body Composition and Sexual Function in Men With COPD, in a 6-Month Randomized Controlled Trial. J Urol. 2005;173(4):1278. doi:10.1097/01.ju.0000155176.16668.1c.
- Xu Q, et al. The association between testosterone, estradiol, estrogen sulfotransferase and idiopathic pulmonary fibrosis: a bidirectional mendelian randomization study. BMC Pulm Med. 2024;24(1):435. doi:10.1186/s12890-024-03198-0.
- Chen Y, et al. Meta-analysis of the association between sex hormones and pulmonary fibrosis. Postgrad Med. 2024;136(5):567-576. doi:10.1080/00325481.2024.2373683.
- Semple PD, Beastall GH, Brown TM, et al. Sex hormone suppression and sexual impotence in hypoxic pulmonary fibrosis. Thorax. 1984;39(1):46-51. doi:10.1136/thx.39.1.46.
- Reyes-García J, et al. Sex Hormones and Lung Inflammation. Adv Exp Med Biol. 2021;1304:259-321. doi:10.1007/978-3-030-68748-9_15.
- Smith AM, Jones RD, Channer KS, Jones TH. Characterization of the vasodilatory action of testosterone in the human pulmonary circulation. Vasc Health Risk Manag. 2008;4(6):1459-1466. doi:10.2147/vhrm.s3995.
- English KM, Jones RD, Jones TH, Morice AH. Gender differences in the vasomotor effects of different steroid hormones in rat pulmonary and coronary arteries. Horm Metab Res. 2001;33(11):645-652. doi:10.1055/s-2001-18689.
- Jones RD, Pugh PJ, Jones TH, Channer KS. Altered circulating hormone levels, endothelial function and vascular reactivity in the testicular feminised mouse. Eur J Endocrinol. 2003;148(1):111-120. doi:10.1530/eje.0.1480111.
- Martin YN, Lahm T. Sex differences in the pulmonary circulation: implications for pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2014;306(9):H1253-H1264. doi:10.1152/ajpheart.00857.2013.
